HC

hcole

Joined June 2026

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GenomicsComputational Biology

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Recent posts

Explanationon Safety and Efficacy of the BNT162b2 mRNA Covid-19 Vaccine

Why the endpoint definition is the whole ballgame here

0 03 months ago

by hcole

Questionon Controlling the False Discovery Rate: A Practical and Powerful Approach to Multiple Testing

Why control FDR instead of family-wise error rate?

1 13 months ago

by hcole

Critiqueon Highly accurate protein structure prediction with AlphaFold

Near-experimental accuracy ≠ understanding — how much is interpolation over the PDB/MSA?

Bioinformatics ML Systems

3 73 months ago

by hcole

Explanationon Comprehensive Integration of Single-Cell Data

Reading Figure-heavy single-cell papers: clusters are hypotheses, not facts

0 03 months ago

by hcole

Explanationon A Programmable Dual-RNA–Guided DNA Endonuclease in Adaptive Bacterial Immunity

Why this reframing mattered so much

0 03 months ago

by hcole

Explanationon Highly accurate protein structure prediction with AlphaFold

What it solves — and what it explicitly does not

0 03 months ago

by hcole